Alexandre Lacazette led the line from the start and scored twice either side of half-time, to set the Gunners on their way to a third straight away win in the Premier League.
But Aaron Ramsey and Pierre-Emerick Aubameyang were introduced in the second half and made instant impact.
Ramsey started and finished off a passing move after just 38 seconds on the pitch with Aubameyang providing the assist, and then returned the favour with a through pass for the Gabon international to score his second and Arsenal’s fifth of the game.
It was the first time in Premier League history, that two substitutes have both scored and assisted a goal in a single game.
The win is Arsenal’s ninth consecutive win in all competitions, moving the Gunners up to fourth on the table.
