Mrs Buhari slammed state Governors and Ministers for failing to provide basic social amenities and infrastructure for the people.
He lamented that things were getting out of hands in the country.
She said rising cases of insecurity, which she said was as a result of injustice, had made it impossible for some Nigerians to travel to their states and villages and live peacefully.
She said her husband cannot handle the challenges facing the nation alone.
Aisha admonished political leaders to work together to bring the country out of the doldrums.
The First Lady spoke at the Nigerian Supreme Council for Islamic Affairs General Assembly and national executive council meeting at the National Mosque in Abuja yesterday.
Lamenting the high rate of insecurity in the country, Aisha said if the needful was not done, Nigerians would regret the outcome of insecurity soon.
She said, “We either fasten our seatbelts and do the needful or we all regret it very soon, because at the rate things are going, things are getting completely out of hands.
“The VP (Yemi Osinbajo) is here. Some ministers are here. They are supposed to do justice to the situation.
“People cannot afford potable water in this country while we have governors. Since this is the highest decision-making body of Islamic affairs, for those that are listening, we should fear God, and we should know that one day, we will return to God and account for our deeds here on earth.
“On this issue of social media, you cannot just sit in the comfort of your house and tweet that the Vice President has resigned. It is a serious issue. If China can control over 1.3 billion people on social media, I see no reason why Nigeria cannot attempt controlling only 180 million people.
“We must do justice to ourselves. Most of us here, as a result of a long time of injustice done to others, cannot go to our villages and sleep with our two eyes closed.
“We all know that my husband has three years to go. We either fasten our seatbelts and do the needful or we all regret it very soon.”